San Francisco 49ers vs Buffalo Bills: Complete Match Player Stats, Highlights, and Key Takeaways

The 49ers vs Buffalo Bills match player stats reveal one of the most exciting and hard-fought games of the season, showcasing elite athleticism, strategy, and determination from both teams. This clash between the San Francisco 49ers and Buffalo Bills wasn’t just another regular-season showdown—it was a battle that highlighted quarterback excellence, defensive resilience, and game-defining moments that had fans on the edge of their seats. From explosive offensive drives to crucial interceptions, the matchup offered everything football enthusiasts crave, making it one of the most talked-about games in recent memory.

Match Overview: 49ers vs Bills Showdown

The clash between the San Francisco 49ers and the Buffalo Bills on December 1, 2024 ended in a dominant 35-10 win for Buffalo. The Bills improved to 10-2 and clinched the AFC East with five games left, while the 49ers fell to 5-7. Buffalo’s balanced attack, efficient offense, and defensive discipline stood out, especially under challenging snowy conditions at Highmark Stadium. The 49ers, on the other hand, struggled to establish rhythm, were impacted by injuries, and turned the ball over multiple times. A succinct but powerful result set the tone for the rest of the season for both sides.

First Half Breakdown: Momentum and Key Plays

From the opening minutes, Buffalo seized control. In the first quarter, after a 33-yard field goal by San Francisco’s Jake Moody, Buffalo answered right back with a Ray Davis 5-yard rushing touchdown. ESPN The second quarter saw the Bills explode: James Cook broke free for a 65-yard TD run and later quarterback Josh Allen hooked up with Mack Hollins for a 7-yard TD pass. At halftime, Buffalo led 21-3, having converted four of their five second-quarter possessions into points. The 49ers, meanwhile, were plagued by turnovers and inability to sustain drives, setting them on the back foot early.

Second Half Highlights: Game-Changing Moments

The third quarter brought another dangerous display from Buffalo. Allen executed a cleverly designed trick play: a pass to Amari Cooper, who lateraled back to Allen for a 9-yard touchdown. The 49ers had a brief spark with Isaac Guerendo’s 15-yard rushing TD, but Buffalo answered again to push the score to 35-10. theScore.com Snow conditions continued to intensify, yet Buffalo remained composed—showing why home-field advantage at Highmark Stadium in winter is real. The 49ers’ key star Christian McCaffrey exited early with a knee injury, further derailing San Fran’s chances.

Offensive Player Stats and Standout Performances

Buffalo’s offense excelled across multiple facets:

• Josh Allen: 13 of 17 passing for 148 yards and 2 TDs, plus 3 rush attempts for 18 yards and a rushing TD making him the first NFL quarterback to record passing, rushing, and receiving touchdowns in the same game.
• James Cook: 14 carries for 107 yards and 1 TD; his 65-yard scamper was the longest run of the night.
• Running Game: Buffalo rushed for 220 yards as a team, outpacing San Fran’s 153.
  For San Francisco:
• Brock Purdy: 11 of 18 passing, 94 yards, no TDs, 2 sacks.
• Rushing: Led by Jordan Mason, 13 carries for 78 yards. But the 49ers could not match the Bills’ tempo.

Defensive Player Stats and Impact Analysis

Buffalo’s defense did its job: three fumbles recovered, two sacks, and constant pressure on the 49ers’ offense. Buffalo Bills Linebacker Terrel Bernard logged nine total tackles while DE Greg Rousseau notched a sack and forced/fumbled. San Fran turned the ball over three times and trailed in time of possession (26:33 vs 33:27). USA TODAY Buffalo’s ability to win the turnover battle and control second-half momentum sealed the outcome well before the final whistle.

Quarterback Comparison: Passing Accuracy and Strategy

Josh Allen showed poise, accuracy, and versatility. His completion rate (76.5%) and lack of turnovers (0 INTs) stood in contrast to Purdy’s quieter night. The 49ers’ offense failed to generate explosive plays despite gaining 239 total yards. Buffalo’s offense operated efficiently averaging 6.6 yards per play vs San Fran’s 5.1. The narrative: Buffalo executed their game plan flawlessly, while the 49ers never caught up.

Running Game Review: Ground Dominance and Yard Gains

Buffalo truly dominated via the ground game: 220+ yards and multiple rushing touchdowns. James Cook’s 65-yard run was a turning point, one that demoralized the 49ers and energized the crowd. Tomlinson-style efficiency showcased serious threat. San Fran had decent numbers (153 rushing yards), but turnovers and penalties killed drives. The Bills’ commitment to the run forced the 49ers to stay honest defensively, opening opportunities for passing plays.

Wide Receivers and Tight Ends: Key Contributions

Buffalo’s receiving corps made big plays in key moments. Mack Hollins grabbed a 7-yard TD in Q2, and Amari Cooper was central to the trick play touchdown. Their yardage may not top leaderboards, but timing and execution mattered. For San Fran, injuries and weather impacted pass-catching ability. Their receivers never broke free consistently, limiting Purdy’s options and allowing the Bills’ defense to stay focused on the run.

Special Teams Performance and Crucial Field Goals

Special teams often decide tight gamesbbut not so here. The Bills blocked two punts and recovered multiple fumbles deep in 49ers territory. Buffalo’s kicker Tyler Bass was perfect on his field goals. The 49ers were less efficient: Moody missed a field goal attempt and their punting average (41.3 yards) lagged behind Buffalo’s (46.7). In the snow, it wasn’t just offense—it was all three phases working together.

Team Statistics: Possession, Penalties, and Efficiency

Buffalo’s superior efficiency across these metrics is evident. While the 49ers amassed some yardage, turnovers and poor third-down conversions killed momentum. The Bills kept drives alive and punished mistakes.

Injury Updates and Player Conditions Post-Match

San Fran lost Christian McCaffrey to a knee injury in the second quarter—a major blow to their offense. The snow and cold conditions also challenged both teams, but Buffalo appeared better prepared. Weather is always a factor in Buffalo, and the 49ers seemed less equipped to adjust mid-game. Their offensive line allowed two sacks and eight lost yardage, signaling deeper concerns beyond just one bad night.

Coach Reactions and Post-Game Interviews

Coach Sean McDermott praised his team’s discipline and readiness under difficult conditions: “We prepared all week for whatever nature gave us and the boys responded.” On the 49ers side, coach Kyle Shanahan admitted the execution just wasn’t there: “We made too many mistakes against a good team. We’ll evaluate and rebound.” Their comments reflect two teams in very different places—one cruising, the other needing serious adjustments.

Fan Reactions and Social Media Buzz

Videos of Allen’s snow-angel celebration went viral across social platforms, symbolizing Buffalo’s confident mindset despite conditions. Meanwhile, 49ers fans flooded forums with frustration over injuries and turnovers. Social analytics show spikes not only in praise for Buffalo’s performance but also in discussions about weather impacts, home-field advantage, and playoff implications. One Reddit thread labelled it “another embarrassed return for the 49ers” after the Super Bowl loss last season. Reddit

Key Takeaways: What This Match Means for Both Teams

• For Buffalo: The win clinched the AFC East early and reaffirmed their status as serious Super Bowl contenders. Their balanced offence and disciplined defense showed championship potential.
• For San Fran: The loss spotlights deeper issues injuries, turnovers, and a lack of consistency. If they hope to recover from last year’s Super Bowl appearance, they must regroup quickly.
• Strategic Insight: Buffalo’s run-first approach and efficiency in third downs stood out. The 49ers lacked their usual explosiveness and couldn’t overcome the mountain they faced in adverse weather.
• Future Impact: The result may influence playoff seeding for Buffalo and force roster changes for San Fran. The margin suggests that even powerhouses can stumble when execution falters.

Conclusion:

The 35-10 result tells more than just a score—it reveals momentum, momentum turned into dominance. The Buffalo Bills not only beat the San Francisco 49ers; they made a statement. Their offense was sharp, defense unrelenting, and environment used to their advantage. For the 49ers, it was a sobering reminder that past success doesn’t guarantee future wins. When conditions turned and mistakes mounted, they slipped. For fans and analysts alike, the takeaway is clear: in the NFL, execution under pressure wins games—not just talent. This matchup will be remembered not only for the scoreboard, but for how Buffalo controlled every phase and left San Fran searching for answers.

FAQs

Who led the game in rushing yards?
James Cook (Bills) rushed for 107 yards and a touchdown. Buffalo Bills

What historic feat did Josh Allen accomplish?
Allen became the first NFL quarterback to record a passing, rushing, and receiving touchdown in the same game.

What was the total time of possession for each team?
49ers held the ball for 26:33, while Bills had 33:27. San Francisco 49ers

How many turnovers did the 49ers commit?
The 49ers committed 3 turnovers; the Bills committed 0.

Did weather play a role in this game?
Yes — heavy snow was present at Highmark Stadium and may have impacted the 49ers more than the Bills, a team more accustomed to those conditions.

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